What is tramadol? How does it work (mechanism of action)?

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Tramadol is a synthetic (man-made) pain reliever (analgesic). Researchers and doctors do not know the exact mechanism of action of tramadol, but it is similar to morphine. Like morphine, tramadol binds to receptors in the brain (narcotic or opioid receptors) that are important for transmitting the sensation of pain from throughout the body to the brain.Tramadol produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation.

he minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent opioid agonists.

Tramadol is now a controlled substance in all 50 U.S. states

The U.S. Drug Enforcement Administration (DEA) announced that tramadol was placed into schedule IV of the Controlled Substances Act (CSA) effective August 18, 2014.

Tramadol is associated with a wide array of side effects

In many people, tramadol is well-tolerated when used for pain, but tramadol can also cause some common and serious side effects.

Dangerous metabolism, drug interactions with tramadol

You probably already suspected that tramadol has drug interactions, but you may not know the extent and seriousness that some of these drug interactions can cause

Tramadol can be habit-forming

Tramadol is structurally related to the opioids like codeine and morphine and can lead to psychological and physical dependence, addiction, and withdrawal.

Tramadol extended-release tablets and capsules are only used by people who are expected to need medication to relieve pain around-the-clock. Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pai

tramadol classification !

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  • Tramadol 100mg
  • Tramadol 500mg
  • Tramadol Injections
Does Tramadol HCL Interact with other Medications?

Types of drugs known to interact with tramadol include

What Tramal is used for

Tramal is a painkiller prescribed to individuals with moderate to severe pain. It can be used by adults and adolescents aged > 12 years.

How Tramal works

ITramal is an analgesic, which means it relieves pain. The active ingredient in Tramal is tramadol hydrochloride. The ways in which it relieves pain are not fully understood, though it is known to affect the areas of the brain which transmit pain signals.

How to use Tramal

The recommended dose is 100–200 mg (1–2 tablets) twice daily, preferably in the morning and evening. Your doctor will adjust the dose depending on your pain and its response to Tramal therapy. Your doctor may prescribe a lower initial starting dose.

Overdose

Overdose from Tramal has been reported rarely. Symptoms of Tramal overdose include miosis (contracted pupils), vomiting, heart and breathing problems, convulsions and unconsciousness

Precautions while taking tramadol

Before taking tramadol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

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